CHARACTERIZATION OF HEMATOPOIESIS IN SICKLE CELL DISEASE BY PROSPECTIVE ISOLATION OF STEM AND PROGENITOR CELLS

Characterization of Hematopoiesis in Sickle Cell Disease by Prospective Isolation of Stem and Progenitor Cells

The consequences of sickle cell disease (SCD) include ongoing hematopoietic stress, hemolysis, vascular damage, and effect of chronic therapies, such as read more blood transfusions and hydroxyurea, on hematopoietic stem and progenitor cell (HSPC) have been poorly characterized.We have quantified the frequencies of nine HSPC populations by flow cyt

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Cecr2 mutant mice as a model for human cat eye syndrome

Abstract Cat eye syndrome (CES), a human genetic disorder caused by the inverted duplication of a region on chromosome 22, has been known since the late 1890s.Despite the significant impact this disorder has on affected individuals, models for CES have read more not been produced due to the difficulty of effectively duplicating the corresponding ch

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